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  • Title: Effect of miconazole on growth and aflatoxin production by Aspergillus parasiticus.
    Author: Buchanan RL, Jones SB, Stahl HG.
    Journal: Mycopathologia; 1987 Dec; 100(3):135-44. PubMed ID: 3696192.
    Abstract:
    At 5 microM, miconazole prevented the growth of Aspergillus parasiticus Speare in a number of media. Sensitivity to miconazole was increased approximately 10-fold in a medium containing glycerol. At sub-inhibitory concentrations, miconazole stimulated aflatoxin synthesis on media which normally support toxin formation. Miconazole inhibited respiration and altered mitochondrial ultrastructure, suggesting that miconazole inhibits growth and stimulates aflatoxin production by depressing mitochondrial activity.
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