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  • Title: Crude oil exposure of early life stages of Atlantic haddock suggests threshold levels for developmental toxicity as low as 0.1 μg total polyaromatic hydrocarbon (TPAH)/L.
    Author: Sørhus E, Sørensen L, Grøsvik BE, Le Goff J, Incardona JP, Linbo TL, Baldwin DH, Karlsen Ø, Nordtug T, Hansen BH, Thorsen A, Donald CE, van der Meeren T, Robson W, Rowland SJ, Rasinger JD, Vikebø FB, Meier S.
    Journal: Mar Pollut Bull; 2023 May; 190():114843. PubMed ID: 36965263.
    Abstract:
    Atlantic haddock (Melanogrammus aeglefinus) embryos bind dispersed crude oil droplets to the eggshell and are consequently highly susceptible to toxicity from spilled oil. We established thresholds for developmental toxicity and identified any potential long-term or latent adverse effects that could impair the growth and survival of individuals. Embryos were exposed to oil for eight days (10, 80 and 300 μg oil/L, equivalent to 0.1, 0.8 and 3.0 μg TPAH/L). Acute and delayed mortality were observed at embryonic, larval, and juvenile stages with IC50 = 2.2, 0.39, and 0.27 μg TPAH/L, respectively. Exposure to 0.1 μg TPAH/L had no negative effect on growth or survival. However, yolk sac larvae showed significant reduction in the outgrowth (ballooning) of the cardiac ventricle in the absence of other extracardiac morphological defects. Due to this propensity for latent sublethal developmental toxicity, we recommend an effect threshold of 0.1 μg TPAH/L for risk assessment models.
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