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  • Title: Automated 3'-H-phosphonate synthesis of oligodeoxyribonucleotides using amidine protected purine synthons.
    Author: Tocík Z, Arnold L, Smrt J.
    Journal: Nucleic Acids Symp Ser; 1987; (18):193-6. PubMed ID: 3697126.
    Abstract:
    Side reaction during phosphitylation of 5'-O-dimethoxytrityl-N2-isobutyryl-2'-deoxyguanosine was observed. As a suitable dG synthon, 5'-O-dimethoxytrityl-N2-dimethylaminomethyl-ene-3'-H-phosphonate was developed and used, along with 3'-H-phosphonates of 5'-O-dimethoxytrityl derivatives of dT, N4--benzoyl-dC and N6-dimethylaminoethylidene-dA, in automated synthesis of several oligodeoxyribonucleotides containing 30-40 bases.
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