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  • Title: Cytokinetic analysis of the expanding Kupffer-cell population in rat liver.
    Author: Bouwens L, Baekeland M, Wisse E.
    Journal: Cell Tissue Kinet; 1986 Mar; 19(2):217-26. PubMed ID: 3698079.
    Abstract:
    Zymosan stimulation in rats provides a useful model for studying the expansion of the Kupffer-cell population in liver, which represents the major population of tissue macrophages. This study, using tritiated-thymidine-labelling experiments, demonstrates that during population expansion at least 90% of the resident macrophages (Kupffer cells) develop proliferative activity. The mean duration of the cell cycle is estimated to be 52 hr, with an S phase of 7 hr. We have calculated that about 75% of population expansion results from local Kupffer-cell replication, whereas the remaining growth results from extrahepatic recruitment of macrophage precursors. These findings conflict with a concept of the mononuclear phagocyte system, which states that resident macrophages are (monocyte-derived) non-dividing end-cells.
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