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  • Title: Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo-[2.2.2]octan-5-trans-ol with antiarrhythmic and other activities. VI.
    Author: Longobardi M, Bargagna A, Schenone P, Filippelli A, Tortora G, Marrazzo R, Marmo E.
    Journal: Farmaco Sci; 1986 Feb; 41(2):151-5. PubMed ID: 3699146.
    Abstract:
    The synthesis of a series of alkyl and aryl amides (IV) starting from 5-trans-(3-aminopropoxy)-N-benzyl-1,2,3,3-tetramethyl-2-azabicyclo [2.2.2] octane is described. Some of compounds (IV) showed a moderate hypotensive activity in rats and infiltration anesthesia in mice. Effects on heart rate in rats and antiarrhythmic activity in mice were practically absent.
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