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  • Title: Structure-analgesic activity relationships in a set of 2-aminobenzamide derivatives.
    Author: Lisciani R, Lembo S, Cozzolino S, La Rotonda MI, Silipo C, Vittoria A.
    Journal: Farmaco Sci; 1986 Feb; 41(2):89-102. PubMed ID: 3699148.
    Abstract:
    A set of 2-aminobenzamide derivatives designed as analgesic following the principles of correlation analysis have been prepared and tested. The analgesic effects shown by these products are similar to those of non-narcotic analgesic drugs; moreover, they do not show antipyretic effects and are inactive or very poor inhibitors of prostaglandin synthesis. Quantitative structure-activity relationships (QSAR) show that the analgesic potency (writhing test) is a function of the octanol-water partition coefficient. The predictive value of a correlation equation previously published is clearly demonstrated.
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