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  • Title: [Advances in enzyme immobilization based on hierarchical porous metal-organic frameworks].
    Author: Chen Y, Zheng H, Cao Y, Yang J, Zhou H.
    Journal: Sheng Wu Gong Cheng Xue Bao; 2023 Mar 25; 39(3):930-941. PubMed ID: 36994563.
    Abstract:
    As an excellent hosting matrices for enzyme immobilization, metal-organic framework (MOFs) provides superior physical and chemical protection for biocatalytic reactions. In recent years, the hierarchical porous metal-organic frameworks (HP-MOFs) have shown great potential in enzyme immobilization due to their flexible structural advantages. To date, a variety of HP-MOFs with intrinsic or defective porous have been developed for the immobilization of enzymes. The catalytic activity, stability and reusability of enzyme@HP-MOFs composites are significantly enhanced. This review systematically summarized the strategies for developing enzyme@HP-MOFs composites. In addition, the latest applications of enzyme@HP-MOFs composites in catalytic synthesis, biosensing and biomedicine were described. Moreover, the challenges and opportunities in this field were discussed and envisioned.
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