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  • Title: Rh(I)-Catalyzed [5 + 2]/[2 + 2] Cycloaddition Cascade to Access a Cyclobutane-Fused [4-5-6-7] Tetracyclic Framework.
    Author: Zhang BH, Bao W, Cheng F, Yu KY, Wang JX, Zhang ZH, Dong LJ, Xue ZS, Zhu DY, Xu XT, Wang SH.
    Journal: Org Lett; 2023 Apr 14; 25(14):2405-2409. PubMed ID: 37014308.
    Abstract:
    A Rh(I)-catalyzed [5 + 2]/[2 + 2] cycloaddition cascade has been developed to afford a complex and highly strained [4-5-6-7] tetracyclic framework in good yields and excellent diastereoselectivities. During this transformation, three rings, three C-C bonds, and four contiguous stereocenters were formed efficiently. Mechanistically, the rare sterically congested multisubstituted cyclobutanes are constructed readily through Michael addition and a Mannich reaction cascade.
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