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  • Title: Asymmetric Palladium-Catalyzed Aminochlorination of Unactivated Alkenes.
    Author: Wang Z, Hou C, Chen P.
    Journal: Org Lett; 2023 Apr 21; 25(15):2685-2690. PubMed ID: 37026673.
    Abstract:
    A novel Pd-catalyzed enantioselective aminochlorination of alkenes via a 6-endo cyclization is reported herein, which provides easy access to a wide array of structurally diverse 3-chloropiperidines in good yields with excellent enantioselectivities. Notably, both an electrophilic chlorination reagent (NCS) and the sterically bulky chiral pyridinyl-oxazoline (Pyox) ligand are crucial to the successful reaction.
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