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  • Title: Characterization of the serotype e polysaccharide antigen of Streptococcus mutans.
    Author: Pritchard DG, Gregory RL, Michalek SM, McGhee JR.
    Journal: Mol Immunol; 1986 Feb; 23(2):141-5. PubMed ID: 3702873.
    Abstract:
    The structure of the Streptococcus mutans serotype e polysaccharide was studied in order to determine the chemical basis of the immunological cross-reactions observed between it and the streptococcal group E polysaccharide. The chemical structure was established using methylation analysis, periodate oxidation, partial methanolysis and 13C NMR spectroscopy. The polysaccharide was found to consist of a polyrhamnose backbone of alternating 2- and 3-linked alpha-L-rhamnose units and sidechain beta-D-glucosyl units linked to the 2-position of rhamnose units in the backbone. This structure of the oligosaccharide repeating unit of the S. mutans serotype e polysaccharide was identical to that of the group-specific polysaccharide of group E Streptococcus. Possible explanations for the previously reported differences in these two polysaccharides are discussed.
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