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  • Title: Plasma from uninephrectomized rats increases 32P incorporation into phospholipids of renal cortical slices.
    Author: Kukolja S, Pokrajac N, Banfić H.
    Journal: Nephron; 1986; 43(1):62-6. PubMed ID: 3703067.
    Abstract:
    Incorporation of 32P into phospholipids of renal cortical slices was studied in vitro after addition of plasma from uninephrectomized or sham-operated rats. Plasma from uninephrectomized rats increased the labeling of phospholipids when obtained within the first hour after uninephrectomy. With different amounts of added plasma a graded response in labeling of phosphatidic acid and phosphatidylinositol was obtained. Phosphatidylcholine labeling also showed a graded response but only if the incubation was prolonged. The results suggest that an early alteration in phospholipid metabolism, particularly of inositol lipids, may play a role in initiation of compensatory renal growth by humoral factor(s).
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