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  • Title: The treatment of passively transferred experimental myasthenia with anti-idiotypic antibodies.
    Author: Souroujon MC, Pachner AR, Fuchs S.
    Journal: Neurology; 1986 May; 36(5):622-5. PubMed ID: 3703261.
    Abstract:
    Experimental autoimmune myasthenia gravis (EAMG) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding site of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.
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