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  • Title: Antimalarials. 4. Trichloronaphthalene amino alcohols.
    Author: Shamblee DA, Gillespie JS.
    Journal: J Med Chem; 1979 Jan; 22(1):86-9. PubMed ID: 370389.
    Abstract:
    An improved procedure for the synthesis of naphthalene amino alcohols is described. Four new compounds were prepared and tested by Rane Laboratories for activity vs. Plasmodium berghei in mice. All compounds were active, the most active being 1-[3-(4-chlorophenyl)-5,7-dichloro-1-naphthyl]-3-(di-n-butylamino)propanol hydrochloride (16b). Structure--activity relationships between the naphthalene and quinoline isosteres are discussed.
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