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  • Title: Effect of dietary vitamin E on the production of platelet 12-hydroxyeicosatetraenoic acid (12-HETE).
    Author: Pritchard KA, Greco NJ, Panganamala RV.
    Journal: Thromb Haemost; 1986 Feb 28; 55(1):6-7. PubMed ID: 3705009.
    Abstract:
    Collagen and thrombin challenged platelets from vitamin E-deficient rabbits generated significantly more 12-HETE when compared to the platelets from vitamin E-supplemented rabbits. Similarly, conversion of arachidonic acid to 12-HETE was increased in platelets from vitamin E-deficient rabbits. These data show that vitamin E plays a role not only in deacylation of platelet phospholipids but also in the lipoxygenase mediated reactions.
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