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  • Title: [Effect of thyroxine on the hemoglobin affinity to oxygen and 2,3-diphosphoglycerate level in rat erythrocytes].
    Author: Sukhomlinov BF, Antoniak GL, Trikulenko AV.
    Journal: Ukr Biokhim Zh (1978); 1986; 58(2):84-6. PubMed ID: 3705208.
    Abstract:
    Affinity of hemoglobin to oxygen was studied in rat erythrocytes under conditions of intraperitoneal administration of thyroxin in a dose of 0.4 mg per 100 g of animal weight each 24 h for five days. A significant right shift of the oxyhemoglobin dissociation curve is observed only on the 6th day simultaneously with the increase of the 2,3-diphosphoglycerate level in erythrocytes in the period under study. The results obtained from the study of the thyroxin effect on the respiratory function of hemoglobin permit recommending it as an antihypoxant.
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