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  • Title: What voltage-sensing phosphatases can reveal about the mechanisms of ion channel regulation by phosphoinositides.
    Author: Okamura Y, Yoshioka D.
    Journal: Biochem Soc Trans; 2023 Apr 26; 51(2):827-839. PubMed ID: 37052219.
    Abstract:
    Many membrane proteins including ion channels and ion transporters are regulated by membrane phospholipids such as phosphoinositides in cell membranes and organelles. Voltage-sensing phosphatase, VSP, is a voltage-sensitive phosphoinositide phosphatase which dephosphorylates PI(4,5)P2 into PI(4)P. VSP rapidly reduces the level of PI(4,5)P2 upon membrane depolarization, thus serving as a useful tool to quantitatively study phosphoinositide-regulation of ion channels and ion transporters using a cellular electrophysiology system. In this review, we focus on the application of VSPs to Kv7 family potassium channels, which have been important research targets in biophysics, pharmacology and medicine.
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