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  • Title: Myometrial activity related to gap junction area in periparturient and in ovariectomized oestrogen treated sheep.
    Author: Verhoeff A, Garfield RE, Ramondt J, Wallenburg HC.
    Journal: Acta Physiol Hung; 1986; 67(1):117-29. PubMed ID: 3705974.
    Abstract:
    Propagation of electrical (EMG) activity in the myometrium may be facilitated by the presence of gap junctions (GJ), leading to improved synchronization of contractility. EMG and mechanical (IUP) activity in relation to GJ area were studied in 9 periparturient and in 2 ovariectomized (OVX) oestradiol-17 beta (E2) treated ewes, chronically instrumented with bipolar electrodes and intrauterine sponge-tip catheters. Myometrial biopsies were taken under epidural anaesthesia at various time intervals around delivery and after intra-arterial administration of 0.1 mg of E2. In pregnant ewes we found a significant increase in the rate of rise and area of IUP cycles during labour. Both were closely related to a significant increase in GJ area. In E2 treated OVX sheep we found a significant increase in GJ area, with a maximum at 24 hours after injection. The increase in GJ area was associated with a significant increase in the rate of rise of IUP cycles. The results of our study support the hypothesis that gap junctions facilitate the spread of EMG activity across the myometrium, which may improve synchronization of uterine contractility during labour.
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