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  • Title: Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture.
    Author: Radmand S, Rezaei H, Zhao H, Rahimpour E, Jouyban A.
    Journal: BMC Chem; 2023 Apr 15; 17(1):37. PubMed ID: 37061696.
    Abstract:
    This work aims to obtain the solubility, density and thermodynamic parameters of deferiprone in propylene glycol and ethanol. For this purpose, a shake-flask technique was applied for solid-liquid equilibration and the spectrophotometry method was employed for solubility measurement. Solubility and density of deferiprone in non-aqueous mixtures of propylene glycol and ethanol were measured in the temperatures 293.2-313.2 K. Some equations including van't Hoff, the Jouyban-Acree, the Jouyban-Acree-van't Hoff, the mixture response surface and modified Wilson equations were used for the mathematical data modeling. The apparent thermodynamic parameters of the deferiprone dissolution process were computed and reported.
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