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  • Title: The effect of cholestyramine on apolipoproteins in cholesterol-fed rabbits.
    Author: Lacombe C, Corraze G, Nibbelink M.
    Journal: Artery; 1986; 13(4):203-12. PubMed ID: 3707359.
    Abstract:
    The changes in apolipoproteins on cholestyramine therapy associated with cholesterol feeding were compared to those observed in cholesterol-fed rabbits. Only one molecular species of apo B, identified as apo B-100, was present whatever the dietary or pharmacological treatment indicating the hepatic origin of apo B-containing lipoproteins in these conditions. Cholestyramine has a clear preventive effect on the rise of apo B and apo E which appear following cholesterol feeding. These changes are highly correlated with those of the plasma cholesterol level. In addition, cholestyramine induced a 50% increase in apo AI compared with normal rabbits. These data strongly confirm the beneficial effects of cholestyramine in the treatment of hypercholesterolemia.
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