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  • Title: [Expression level of miR-199b in human colorectal cancer tissues and its correlation with clinicopathological features and prognosis of patients].
    Author: Ma X, Yuan W, Ma J.
    Journal: Zhonghua Zhong Liu Za Zhi; 2023 Apr 23; 45(4):330-334. PubMed ID: 37078214.
    Abstract:
    Objective: To investigate the relationship between miR-199b and clinicopathologic features and prognosis of patients with colorectal cancer. Methods: Cancer tissues and adjacent normal tissues of 202 patients with colorectal cancer treated in Cancer Hospital of Chinese Academy of Medical Sciences from March to December 2011 were collected. Reverse transcription-quantitative real-time polymerase chain reaction was used to detect the expression level of miR-199b in colorectal cancer tissues and corresponding adjacent normal tissues. Kaplan-Meier method and Log rank test were used for survival analysis, and receiver operating characteristic (ROC) curve was used to evaluate the prognostic value of miR-199b in colorectal cancer patients. Results: The relative expression level of miR-199b in colorectal cancer tissues (-7.88±0.11) was lower than that in adjacent normal tissues (-6.49±0.12, P<0.001). The expression level of miR-199b in colorectal cancer tissues with lymph node metastasis (-7.51±0.14) was higher than that in colorectal cancer tissues without lymph node metastasis (-8.23±0.17, P<0.001). The relative expression levels of miR-199b in stage Ⅰ/Ⅱ, Ⅲ and Ⅳ colorectal cancer tissues were gradually increased, which were -8.26±0.17, -7.70±0.16 and -6.57±0.27, respectively, and the difference was statistically significant (P<0.001). The 5-year survival rates of patients with high and low expressions of miR-199b were 75.6% and 84.6%(P=0.045) respectively. ROC curve showed that when miR-199b was -7.965, the area under the curve was 0.578 (95% CI: 0.468, 0.688). Conclusion: The high expression of miR-199b in colorectal cancer tissues is associated with late TNM stage, lymph node metastasis and poor prognosis in colorectal cancer patients, and miR-199b may be used as a potential marker for postoperative progress and prognosis in colorectal cancer patients. 目的： 探讨miR－199b与结直肠癌患者临床病理特征以及预后的关系。 方法： 收集2011年3—12月于中国医学科学院肿瘤医院接受治疗的202例结直肠癌患者的癌组织及癌旁正常组织，采用实时荧光定量PCR方法检测结直肠癌组织及相应癌旁正常组织中miR－199b的表达水平，生存分析采用Kaplan－Meier法和Log rank检验，受试者工作特征(ROC)曲线评估miR－199b预测结直肠癌患者预后的价值。 结果： 结直肠癌组织中miR－199b的相对表达水平(－7.88±0.11)低于癌旁正常组织(－6.49±0.12，P<0.001)。伴有淋巴结转移的结直肠癌组织中miR－199b的表达水平(－7.51±0.14)高于无淋巴结转移的结直肠癌组织(－8.23±0.17，P<0.001)。miR－199b在Ⅰ~Ⅱ期、Ⅲ期和Ⅳ期结直肠癌组织中相对表达水平逐渐升高，分别为－8.26±0.17、－7.70±0.16、－6.57±0.27，差异有统计学意义(P<0.001)。miR－199b高表达组患者的5年生存率(75.6%)低于低表达组患者(84.6%，P＝0.045)。ROC曲线显示，当miR－199b为－7.965时，曲线下面积为0.578(95% CI：0.468~0.688)。 结论： 结直肠癌组织中高表达miR－199b与结直肠癌患者TNM分期晚、淋巴结转移以及不良预后有关，miR－199b可能作为结直肠癌患者术后疾病进展及预后的潜在标志物。.
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