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  • Title: Iron mobilisation from lactoferrin by chelators at physiological pH.
    Author: Kontoghiorghes GJ.
    Journal: Biochim Biophys Acta; 1986 Jun 19; 882(2):267-70. PubMed ID: 3708002.
    Abstract:
    Several alpha-ketohydroxypyridine, 2-hydroxypyridine N-oxide and 8-hydroxyquinoline chelators were shown to mobilise iron from diferric 59Fe-labelled human lactoferrin at physiological pH without the use of mediators or reducing agents. 1,2-Dimethyl-3-hydroxypyrid-4-one was found to be the most effective chelator, removing 90% of 59Fe from [59Fe]lactoferrin, in contrast to desferrioxamine, which was ineffective under the same conditions.
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