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  • Title: [Metabolism of histones and non-histone proteins in liver cell nuclei and chromatin from rats of various ages].
    Author: Klimenko AI, Malyshev AB, Kulachenko BV.
    Journal: Biokhimiia; 1986 Apr; 51(4):553-61. PubMed ID: 3708012.
    Abstract:
    The metabolism of various classes of histones and nonhistone proteins in intact nuclei and in liver chromatin of albino Wistar rats aged 1, 3, 12 and 24 months, was studied. It was shown that in the course of postnatal development the metabolism of nonhistone proteins extracted with 0.14 M NaCl in murine liver is increased. Later in ontogenesis, the incorporation of labeled precursors into proteins HMG 14 and HMG 17 decreases; the specific radioactivity of proteins HMG 1 + 2 is higher in 3- and 24-month-old animals. The intensity of metabolism of nonhistone proteins and histones is higher within the composition of the chromatin complex than in the intact nucleus at all stages of postnatal development. Among other histone proteins, histones H1 are characterized by the highest level specific radioactivity in rats of all age groups.
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