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  • Title: [Effect of perfluorodecalin and perfluorotributylamine on the liver cytochrome P-450 system].
    Author: Khlopushina TG, Kovalev IE, Lysenkova EM.
    Journal: Biokhimiia; 1986 Apr; 51(4):664-7. PubMed ID: 3708015.
    Abstract:
    The effect of a single intraperitoneal injection of perfluorodecaline (0.5 ml) and perfluorotributylamine on the cytochrome P-450-dependent monooxygenase system of male hybrid mouse (CBA X C57Bl) liver was studied. It was shown that perfluorodecaline is a potent inducer of the cytochrome P-450 system in the liver. The sharp increase of the cytochrome P-450 content and of the enzymatic activity was observed within 5 months. The biological effect of perfluorotributylamine on the monooxygenase system of the liver was much less pronounced. A slight inhibition of the cytochrome P-450 system was observed at short times after the injection followed by its slight stimulation after 2 weeks; 30 days thereafter all the parameters under study returned to control values.
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