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  • Title: [Formation of thrombin and its inactivation by antithrombin III following repeated intravenous injections of tissue thromboplastin in animals].
    Author: Pastorova VE.
    Journal: Biull Eksp Biol Med; 1986 May; 101(5):527-9. PubMed ID: 3708129.
    Abstract:
    A breach in the inactivation of thrombin activity by antithrombin III following numerous repeated intravenous injections of tissue thromboplastin to albino rats was established. Seven injections of tissue thromboplastin to animals (at 30-40 min-interval) caused functional exhaustion of anticoagulation system and increased thrombin blood circulation level.
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