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  • Title: The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs.
    Author: Fitzgerald MF, Moncada S, Parente L.
    Journal: Br J Pharmacol; 1986 May; 88(1):149-53. PubMed ID: 3708213.
    Abstract:
    The release of platelet-activating factor (Paf-acether) and of its inactive precursor/metabolite lyso-platelet activating factor (lyso-Paf) from control and sensitized guinea-pig isolated lungs challenged with antigen was investigated. Control guinea-pig lungs perfused either through the pulmonary circulation or through the airways and challenged with antigen did not release Paf-acether. Sensitized guinea-pig isolated lungs perfused through the pulmonary circulation and challenged with antigen released lyso-Paf but not Paf-acether. Sensitized guinea-pig isolated lungs perfused through the airways and challenged with antigen released three times more lyso-Paf and also Paf-acether. These results support a possible role for Paf-acether in respiratory anaphylaxis in the guinea-pig.
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