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  • Title: GABA in the PNS: demonstration in enteric neurons.
    Author: Baetge G, Gershon MD.
    Journal: Brain Res Bull; 1986 Mar; 16(3):421-4. PubMed ID: 3708394.
    Abstract:
    The hypothesis that gamma-aminobutyric acid (GABA) is a peripheral neurotransmitter was tested by determining whether GABA is present in enteric neurons. GABA was detected in the quail gut using high pressure liquid chromatography. GABA-like immunoreactivity was found in both enteric neural plexuses. Only a few neuronal perikarya, but many fibers were stained in each. GABA-immunoreactive neurons survived for over a week in vitro; therefore, they must be intrinsic to the bowel. These and earlier observations indicate that GABA is a peripheral (enteric) as well as a central neurotransmitter.
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