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  • Title: Penetration of ciclacillin into bronchial secretions.
    Author: Bone M, Symonds J, Dougan P.
    Journal: Chemioterapia; 1986 Apr; 5(2):105-8. PubMed ID: 3708715.
    Abstract:
    The penetration of ciclacillin into bronchial secretions was investigated in 105 patients undergoing bronchoscopy after a single oral dose of 500 mg ciclacillin. Comparison was made with 26 patients who received 500 mg ampicillin by mouth. Over a 6 to 8 hour period, ciclacillin achieved significantly higher levels in bronchial secretions but no statistically significant difference between serum ampicillin and ciclacillin levels was detected.
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