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  • Title: Prevention of cyclosporine (CyA) nephrotoxicity by synthetic prostaglandins.
    Author: Makowka L, Lopatin W, Gilas T, Falk J, Phillips MJ, Falk R.
    Journal: Clin Nephrol; 1986; 25 Suppl 1():S89-94. PubMed ID: 3708941.
    Abstract:
    Acute and chronic nephrotoxicity directly attributable to cyclosporine (CyA) administration remains an obstacle to its successful use. The studies presented in this report characterize the cytoprotective properties of 16,16-dimethyl prostaglandin E2 in a lethal CyA-induced nephrotoxic rodent model. Wistar-Furth rats (200-250 g) receiving CyA alone (100 mg/kg/day) showed marked deterioration in renal function with severe histologic renal lesions and death of the majority of animals by day 7. The prostaglandin treated group (10/micrograms/kg/day) administered concomitantly with CyA demonstrated near normal renal function and histology by the eighth day after CyA discontinuation, and in a significant improvement in animal survival of 85% (p less than 0.001, n = at least 20 rats/group). These studies demonstrate a novel approach to a major problem with cyclosporine and should have exciting clinical potential.
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