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  • Title: Cytoplasmic free [Ca2+] is not increased in the platelets of deoxycorticosterone-salt and spontaneously hypertensive rats.
    Author: Murakawa K, Kanayama Y, Kohno M, Kawarabayashi T, Yasunari K, Takeda T, Hyono A.
    Journal: Clin Sci (Lond); 1986 Jul; 71(1):121-3. PubMed ID: 3709071.
    Abstract:
    The cytoplasmic free calcium concentration ([Ca2+]i) in the platelets of spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), deoxycorticosterone-salt hypertensive rats (DOC) and normotensive Sprague-Dawley rats (SD) was measured with the fluorescent dye, quin-2-tetra-acetoxymethyl ester. No significant difference in platelet [Ca2+]i was found between SHR and WKY or between DOC and SD rats. No correlations were found between systolic blood pressure and [Ca2+]i. These results suggest that the elevation of platelet [Ca2+]i does not necessarily accompany hypertension in rats.
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