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  • Title: Anticholinesterase activity of a new carbamate, heptylphysostigmine, in view of its use in patients with Alzheimer-type dementia.
    Author: Brufani M, Marta M, Pomponi M.
    Journal: Eur J Biochem; 1986 May 15; 157(1):115-20. PubMed ID: 3709528.
    Abstract:
    The anticholinesterase activity of a new carbamate, heptylphysostigmine, was studied in vitro. This compound is a competitive inhibitor of acetylcholinesterase (or true cholinesterase) having Ki = (1 +/- 0.5) X 10(-7) M. The inhibition was instantaneous at the onset and did not diminish with prolonged incubation of the drug and enzyme.
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