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  • Title: Effect of terguride on prolactin levels in normal, puerperal and hyperprolactinaemic women.
    Author: Venturini PL, Horowski R, Valenzano M, Costantini S, Fasce V, Gorlero F, Rainer E, De Cecco L.
    Journal: Eur J Clin Pharmacol; 1986; 30(2):195-7. PubMed ID: 3709645.
    Abstract:
    Terguride, is an 8 - alpha - ergoline derived from lisuride, acts as a partial dopamine (DA) agonist. The effect and tolerance of terguride has been investigated by an acute administration of 0.2 mg p.o. to 8 normal women, 8 patients with hyperprolactinaemia and 8 women with puerperal hyperprolactinaemia. Prolactin (PRL) levels were markedly suppressed in all subjects, with no significant differences between the groups. Treatment for 5 days with terguride 0.4 mg/day or 0.8 mg/day was studied as an inhibitor of lactation. PRL levels were suppressed in a dose-related manner. No untoward side-effects were noted.
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