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Title: Peroxisomal alanine:glyoxylate aminotransferase deficiency in primary hyperoxaluria type I. Author: Danpure CJ, Jennings PR. Journal: FEBS Lett; 1986 May 26; 201(1):20-4. PubMed ID: 3709805. Abstract: Activities of alanine:glyoxylate aminotransferase in the livers of two patients with primary hyperoxaluria type I were substantially lower than those found in five control human livers. Detailed subcellular fractionation of one of the hyperoxaluric livers, compared with a control liver, showed that there was a complete absence of peroxisomal alanine:glyoxylate aminotransferase. This enzyme deficiency explains most of the biochemical characteristics of the disease and means that primary hyperoxaluria type I should be added to the rather select list of peroxisomal disorders.[Abstract] [Full Text] [Related] [New Search]