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  • Title: Isolation and characterization of variant IGF-1 as well as IGF-2 from adult human brain.
    Author: Carlsson-Skwirut C, Jörnvall H, Holmgren A, Andersson C, Bergman T, Lundquist G, Sjögren B, Sara VR.
    Journal: FEBS Lett; 1986 May 26; 201(1):46-50. PubMed ID: 3709807.
    Abstract:
    The forms of somatomedin present in the adult human brain have been characterized in this study. Two peptides were purified by acidification, size exclusion chromatography, affinity chromatography, FPLC and HPLC. Structural analysis identified these peptides as the variant form of IGF-1 with a truncated N-terminal region earlier isolated from human fetal brain and IGF-2. The presence of the truncated IGF-1 variant and IGF-2 in the human CNS suggests their role as neuropeptides.
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