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  • Title: Motor endplate involvement in the extraocular muscles of the myotonic rat.
    Author: Pachter BR, Eberstein A.
    Journal: Graefes Arch Clin Exp Ophthalmol; 1986; 224(4):325-9. PubMed ID: 3710188.
    Abstract:
    The motor endplates from the extraocular muscles of rats administered 20,25-diazacholesterol were examined by electron microscopy. Many anomalies were found at various levels of the junctional complex. Electron microscopy showed disrupted sole-plate nuclei, disruptions of the junctional sarcoplasm, atypical sarcoplasmic extensions, simplified postsynaptic areas, and interposition of Schwann cell cytoplasm between axonal terminal and muscle fiber with a reduplication of basement membrane, as well as atrophic and disrupted axonal terminals. These data indicate that the motor endplate is affected as well as the muscle fiber in myotonic dystrophy.
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