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  • Title: A family with allo-immune neonatal neutropenia: group-specific pathogenicity of maternal antibodies.
    Author: Verheugt FW, van Noord-Bokhorst JC, von dem Borne AE, Engelfriet CP.
    Journal: Vox Sang; 1979; 36(1):1-8. PubMed ID: 371130.
    Abstract:
    A family is presented, in which the mother developed strong neutrophil granulocyte-specific antibodies with the specificity anti-NA. The first and third children, both NA1-positive, suffered from severe transient neonatal neutropenia, but the second child, NA1-negative, did not. Anti-NA1 antibodies were detectable in the serum of one affected child and the antibody level was directly related to the extent of neutropenia. The incidence of granulocyte-specific antibodies in 198 pregnant women was determined and found to be low.
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