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  • Title: Chronic autoimmune neutropenia due to anti-NA1 antibody.
    Author: Valbonesi M, Campelli A, Marazzi MG, Cottafava F, Jannuzzi C.
    Journal: Vox Sang; 1979; 36(1):9-12. PubMed ID: 371132.
    Abstract:
    A 12-month-old child neutropenic since the age of 8 months, was referred to our institute for a sepsis from Candida albicans. On exploring the cause of neutropenia, an anti-NA1 antibody could be detected in the patient's serum. This antibody seemed to be responsible for the neutropenia because the child's PMN type was NA1+. The reactivity of the autoantibody with the patient's own granulocytes was confirmed by direct and indirect immunofluorescence studies performed on blood and marrow cells. A reduced number of T lymphocytes with poor PHA responsivity has been interpreted as the possible cause of the autoimmune disease. Steroid therapy did not cure the neutropenia but the child's general condition improved.
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