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  • Title: Inhibitory effect of acyclovir on the growth of Inoue-Melnick virus isolated from cerebrospinal fluid.
    Author: Nishibe Y, Inoue YK.
    Journal: J Med Virol; 1986 Apr; 18(4):309-15. PubMed ID: 3711867.
    Abstract:
    Inoue-Melnick virus (IMV) was isolated from the cerebrospinal fluid of patients with chronic neurologic disorders. The effect of acyclovir (ACV), 9-(2-hydroxyethoxymethyl)-guanine, on the growth of IMV was studied in human diploid cell cultures. ACV markedly inhibited the multiplication of all three IMV serotypes in vitro with the same inhibitory effect. By passage of IMV in the presence of ACV in the medium, ACV-resistant mutants of three IMV serotypes were easily isolated.
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