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  • Title: Serum separation abnormality in a multiple myeloma patient.
    Author: Zaharudin MR, C Thambiah S, Samsudin IN, A Hamid H.
    Journal: Malays J Pathol; 2023 Apr; 45(1):123-127. PubMed ID: 37119252.
    Abstract:
    INTRODUCTION: M-protein secreted by myeloma cells do not only contribute to myeloma-related complications but is also a well-recognised source of interference in laboratory assays. We describe a case of a 62-year-old woman whose blood sample showed improper serum separation even after resampling. CASE REPORT: Centrifugation of a biochemistry specimen in a serum-separator tube received by the laboratory failed to separate any serum, nor did repeating the process at a longer duration. Repeat sampling only yielded a small volume of serum from which highly elevated total protein was noted upon analysis. Additional history from the treating clinician unveiled a diagnosis of multiple myeloma in this patient. DISCUSSION: This case represents one of the rare, but significant pre-analytical interferences caused by M-proteins.
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