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  • Title: Intractable primary infertility in women exposed to diethylstilbestrol in utero.
    Author: Berger MJ, Alper MM.
    Journal: J Reprod Med; 1986 Apr; 31(4):231-5. PubMed ID: 3712361.
    Abstract:
    Fertility factors were examined in 50 women with primary infertility and presumed in utero diethylstilbestrol (DES) exposure and in 50 age-matched controls. Uterine deformities and endometriosis were more frequent in the DES-exposed women than the controls. When managed from one to four years, only 4% of DES-exposed women with primary infertility conceived (with no conceptions resulting in a viable fetus) as compared to 44% of controls. Primary infertility of one to two years' duration with uterine deformities characteristic of DES exposure seems to signal a poor prognosis for pregnancy despite treatment of identifiable fertility factors.
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