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  • Title: Crystallization of a DNA tridecamer d(C-G-C-A-G-A-A-T-T-C-G-C-G).
    Author: Saper MA, Eldar H, Mizuuchi K, Nickol J, Appella E, Sussman JL.
    Journal: J Mol Biol; 1986 Mar 05; 188(1):111-3. PubMed ID: 3712441.
    Abstract:
    Crystals of the DNA tridecamer d(C-G-C-A-G-A-A-T-T-C-G-C-G) have been grown by the vapor-diffusion technique with 2-methyl-2,4-pentanediol as precipitant. They are monoclinic space group C2, with a = 79.6 A, b = 43.1 A, c = 24.9 A and beta = 98.7 degrees. Previous nuclear magnetic resonance studies predicted that this tridecamer forms a duplex similar to the B DNA dodecamer, d(C-G-C-G-A-A-T-T-C-G-C-G), except for an extra adenosine residue that is stacked within the helix but remains unpaired: (formula; see text) Preliminary X-ray diffraction studies confirmed that the tridecamer is in the B DNA conformation, consistent with the nuclear magnetic resonance results.
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