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  • Title: [Content of A-, G- and M-class immunoglobulins in adults perorally immunized with a liver Sonne dysentery vaccine].
    Author: Kuz'min SN, Belaia IuA, Birkovskiĭ IuE, Milovanova LP, Pavlova LI.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1978 Sep; (9):47-52. PubMed ID: 371307.
    Abstract:
    The authors studied the immunological shifts in the blood and saliva of 357 adults immunized with live enteral dysentery Sonne vaccine from a spontaneous mutant according to different schemes (1, 2, 3, 4 injections at 2--3-day intervals. The general level of IgA, IgG, and IgM increased during the immunization; there was also an elevation of the specific antibodies level of these classes in the blood of the persons vaccinated. Accretion was the greatest of IgA both in the blood and in saliva of the immunized persons; this pointed to a marked, chiefly local, immunological activity of the vaccine. As shown, during the immunization the rise and the changes in the antibody level of various immunoglobulin classes differed from such in dysentery infection; in the latter case, along with the IgA-antibodies there was a marked elevation of the IgG- and IgM-antibodies level. It is supposed that there was a possibility of a changed of a 4-time immunization scheme to-3-time one, with increase of intervals between the vaccine administration.
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