These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Cerebral venous thrombosis associated with the use of oral contraceptives].
    Author: Tsuboi K, Maki Y, Kamezaki T, Kobayashi E, Meguro K.
    Journal: No Shinkei Geka; 1986 Mar; 14(4):521-6. PubMed ID: 3713978.
    Abstract:
    The entity of cerebrovascular diseases associated with the use of oral contraceptives is well known but quite rare in Japan in contrast to Western countries. We recently encountered a 38 years old female with cerebral venous thrombosis considered to be caused by oral contraception. This patient took oral contraceptives for 17 days following therapeutic abortion, and was transferred to our hospital because of disturbed consciousness. CT scans disclosed a right temporo-occipital subcortical hemorrhagic infarction and bilateral thalamic infarction. Cerebral angiograms showed non-filling of cortical veins in the same area. The internal cerebral vein, vein of Galen and right transverse sinus were not visualized either. The hematoma and necrotic tissue were removed to avoid farther neurological deterioration. The brain was swollen and hyperemic, and thrombosed cortical veins were clearly recognized at operation. Twelve cases, including ours, of cerebrovascular diseases associated with oral contraception were reported up to now in Japan, and only 3 of them were diagnosed objectively as venous or sinus thrombosis. The average age of these 12 cases was 34 years old and many of them experienced abortion or therapeutic abortion. There was no relationship between the dose of estrogen and the onset of cerebrovascular diseases. We believe that the onset of this pathological state is based on gynecological hypercoagulable state, and the oral contraception may play a role of a trigger. Oral contraception should be contraindicated in patients with gynecological hypercoagulable state, hypertension and/or smoking habit. The entity of cerebrovascular diseases associated with the use of oral contraceptives (OCs) is well-known but quite rare in Japan in contrast to the Western countries. The authors recently encountered a 38 year old female with cerebral venous thrombosis considered to be the result of OCs. This patient took OCs for 17 days following therapeutic abortion and was transferred to the study hospital because of disturbed consciousness. CT scans disclosed a right tempro-occipital subcortical hemorrhagic infarction and bilateral thalamic infarction. Cerebral angiograms showed nonfilling of cortical veins in the same area. The internal cerebral vein, vein of Galen, and right transverse sinus were not visualized either. The hematoma and necrotic tissue were removed to avoid further neurological deterioration. The brain was swollen and hyperemic and thrombosed cortical veins were clearly recognized at the time of operation. 12 such cases of OC-related cerebrovascular disease, in including this 1 have now been reported in Japan, and only 3 of them were diagnosed objectively as nous or sinus thrombosis. The average age for these 12 cases was 34 years old, and many of these women experienced abortion or therapeutic abortion. There was no relationship between the dosage of estrogen and the onset of cerebrovascular disease. The authors believe that the onset of this pathological state is the result of a gynecological hypercoagulable state and OCs may have served as a catalyst. OCs are contraindicated in patients with gynecological hypercoagulability, hypertension, or who smoke. (author's modified)
    [Abstract] [Full Text] [Related] [New Search]