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  • Title: Effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on hippocampal paired-pulse inhibition in vivo.
    Author: Rock DM, Taylor CP.
    Journal: Neurosci Lett; 1986 Apr 24; 65(3):265-70. PubMed ID: 3714109.
    Abstract:
    The effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on paired-pulse inhibition were assessed in the intact rat hippocampus. Diazepam (4 mg/kg i.p.) and pentobarbital (15 mg/kg i.p.) increased inhibition over control levels, while phenytoin (15 mg/kg i.p.) and pentylenetetrazol (20 mg/kg i.p.) decreased inhibition from control levels. The present results with diazepam, pentobarbital and pentylenetetrazol confirm previous reports. However, the present results indicate that augmentation of GABA-ergic inhibition is not involved in the anticonvulsant action of phenytoin.
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