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  • Title: Age-dependent cardiovascular effects of verapamil in newborn swine.
    Author: Jarenwattananon M, Buckley BJ, Gootman N, Kaplan NA.
    Journal: Pediatr Res; 1986 May; 20(5):428-32. PubMed ID: 3714351.
    Abstract:
    Since there are limited studies concerning the hemodynamic effects of verapamil in pediatric patients, cardiovascular effects of clinical doses (100 or 300 micrograms/kg) of verapamil, given as a 2-min intravenous infusion, were examined in sodium pentobarbital anesthetized swine, aged 1 day (n = 15) and 2 wk (n = 18). Aortic and left ventricular pressures, index of left ventricular contractility, heart rate, and phasic superior mesenteric, renal, and femoral arterial flows were recorded; mean aortic pressure and vascular resistances were calculated. Maximum changes in cardiovascular function (mean % delta +/- SEM) occurred at the end of the infusion. Mean aortic pressure and index of left ventricular contractility decreased in all animals; responses were larger in magnitude with the higher dose. By 30 min after infusion of 300 micrograms/kg verapamil had ended, mean aortic pressure in both 1 day and 2 wk olds and index of left ventricular contractility and femoral flow in 1 day olds were still decreased. During infusion of verapamil, heart rate decreased (-11.6 +/- 2.9) to the high dose in 1 day olds but increased (+6.4 +/- 2.7) to 100 and 300 micrograms/kg verapamil in 2 wk olds. After infusion of 300 micrograms/kg verapamil ended, heart rate decreased and reached the nadir (-10.0 +/- 2.9) by 10 min in 2 wk olds. Decreases in renal resistance (-7.6 +/- 1.7) were not dose dependent while superior mesenteric resistance decreased (-12.9 +/- 2.7) only to low dose verapamil in 2 wk olds. In 1 day olds decreases in renal and superior mesenteric resistance were not sustained throughout the infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
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