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  • Title: The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism.
    Author: Adlanmerini M, Lazar MA.
    Journal: Endocrinology; 2023 Apr 17; 164(6):. PubMed ID: 37149727.
    Abstract:
    REV-ERB nuclear receptors are potent transcriptional repressors that play an important role in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its largely redundant isoform REV-ERBβ in a murine tissue-specific manner have shed light on their specific functions in clock mechanisms and circadian metabolism. This review highlights recent findings that establish REV-ERBs as crucial circadian timekeepers in a variety of tissues, regulating overlapping and distinct processes that maintain normal physiology and protect from metabolic dysfunction.
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