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  • Title: The metabolism of 9-methylanthracene by rat-liver microsomal preparations.
    Author: Lamparczyk HS, McKay S, Farmer PB, Cary PD, Grover PL, Sims P.
    Journal: Xenobiotica; 1986 Apr; 16(4):325-33. PubMed ID: 3716454.
    Abstract:
    The metabolism of 9-methylanthracene by liver microsomal preparations from 3-methylcholanthrene-treated rats was examined. The principal metabolites identified were 9-hydroxymethylanthracene, the 1,2- and 3,4-dihydrodiols of the parent hydrocarbon and the 3,4-dihydrodiol of the 9-hydroxymethyl derivative. A small amount of a product that appeared to be a phenolic derivative of the hydrocarbon was also formed. The structures of the major metabolites were confirmed by u.v., n.m.r., and mass-spectral analysis and, wherever possible, by direct comparison of their chromatographic properties with those of the authentic compounds. 9-Hydroxymethylanthracene was further metabolized by rat-liver microsomal preparations to the 3,4-dihydrodiol but not to the related 1,2-dihydrodiol.
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