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  • Title: A prospective randomized trial of vagotomy in chronic duodenal ulceration.
    Author: Koffman CG, Elder JB, Gillespie IE, Ganguli PC, Ostick DG, Cowley DJ, Dymock IW, Tweedle DE, Schofield PF, Pengelly CD, Shafiq M, Shreeve DR, Palmer M.
    Journal: Br J Surg; 1979 Mar; 66(3):145-8. PubMed ID: 371737.
    Abstract:
    In a prospective, randomized trial, 76 patients with duodenal ulceration treated by truncal vagotomy and pyloroplasty were compared with 77 patients who underwent highly selective vagotomy. A total of 149 patients was followed up for from 1 to 4 years, the average follow-up period being 2.6 years. There was no operative mortality and no significant difference in postoperative morbidity between the two groups. The incidence of recurrent ulceration was greater after highly selective vagotomy, but this difference was not statistically significant. The clinical results were comparable in each group, and although the incidence of diarrhoea and dumping was greater after vagotomy and pyloroplasty, this difference was not statistically significant.
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