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  • Title: Phase I trial of a new form of an oral administration of VP-16-213.
    Author: Lau ME, Hansen HH, Nissen NI, Pedersen H.
    Journal: Cancer Treat Rep; 1979 Mar; 63(3):485-7. PubMed ID: 371801.
    Abstract:
    A new oral form of VP-16-213 consisting of a hydrophilic soft gelatin capsule containing a VP-16-213 solution was tested for toxicity in 26 patients. The drug was administered at four different dose levels, 350, 500, 650, and 750 mg/m2, in 5-day courses every 21-28 days. A dose-dependent effect was observed with regard to hematologic toxicity and alopecia. It is concluded that the drinking ampules of VP-16-213 can be replaced with the new oral capsules with a recommended initial dose of 100-130 mg/m2 given in 5-day courses every 21-28 days.
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