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  • Title: Pediatric combined living donor liver and kidney transplantation for primary hyperoxaluria type 2.
    Author: Hosaagrahara Ramakrishna S, Hassan A, Kasala MB, Perumal K, Venkategowda C, Malleeswaran S, Periasamy M, Kaliyaperumal M, Patcha RV, Varghese J, Reddy MS.
    Journal: Am J Transplant; 2023 Oct; 23(10):1622-1625. PubMed ID: 37187295.
    Abstract:
    We report the case of a 12-year-old boy with primary hyperoxaluria type 2 (PH2) presenting with end-stage renal disease and systemic oxalosis who underwent a combined living donor liver and kidney transplant from 3 donors, 1 of whom was a heterozygous carrier of the mutation. Plasma oxalate and creatinine levels normalized immediately following the transplant and remain normal after 18 months. We recommend combined liver and kidney transplantation as the preferred therapeutic option for children with primary hyperoxaluria type 2 with early-onset end-stage renal disease.
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