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  • Title: Pharmacokinetics of antipyrine in epileptic patients.
    Author: Rimmer EM, Routledge PA, Tsanaclis LM, Richens A.
    Journal: Br J Clin Pharmacol; 1986 May; 21(5):511-4. PubMed ID: 3718808.
    Abstract:
    The pharmacokinetics of antipyrine were examined after oral and intravenous administration to 20 epileptic subjects receiving antiepileptic drug therapy. Bioavailability was essentially complete (mean bioavailability 101.2% +/- 14.4 (s.d.] indicating that even in enzyme induced subjects, antipyrine behaves as a restrictively eliminated compound with negligible presystemic elimination in the gut or liver. Of the generally used measures of enzyme induction (oral clearance, oral half-life and intravenous half-life) oral clearance was the most closely related to the intravenous clearance of antipyrine (r = 0.919, P less than 0.001). Oral antipyrine administration is an alternative to intravenous administration in epileptic subjects who are enzyme-induced.
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